The Buffalo Bandits aim for a third consecutive title as the 2025 NLL playoffs commence with the quarterfinals. The Bandits have a strong record against the San Diego Seals, but this playoff meeting is their first. The Halifax Thunderbirds have their first home playoff game. The Calgary Roughnecks have top scorers in playoff history. The Georgia Swarm and Saskatchewan Rush have a history of intense matchups. The Vancouver Warriors make their first playoff appearance as such, while the Rochester Knighthawks seek their first win under the new franchise.

• Buffalo Bandits vs San Diego Seals: The Bandits are 5-1 against the Seals all-time, with a split in the regular-season series. Dhane Smith has 188 career playoff points.
• Calgary Roughnecks vs Halifax Thunderbirds: This is the Thunderbirds' first home playoff game and they seek their first win since moving to Halifax.
• Georgia Swarm vs Saskatchewan Rush: The Swarm won the NLL championship in 2017 defeating the Rush.
• Rochester Knighthawks vs Vancouver Warriors: The Warriors have been on a winning streak since acquiring a star goaltender.