2025 AFC South Betting Preview: Texans Lead, But Can Colts, Jaguars, or Titans Surprise?
Explore the 2025 AFC South betting landscape as the Houston Texans aim for a third straight title, while the Jaguars, Colts, and Titans look to challenge.

The Houston Texans are the clear favorites to secure their third consecutive AFC South title in 2025, with even-money odds. However, the competition is heating up with the Jacksonville Jaguars (+300), Indianapolis Colts (+350), and Tennessee Titans (+750) all poised to make a statement.
Key Contenders
- Houston Texans: Back-to-back division champions, the Texans are aiming for a historic three-peat. With a strong roster and consistent performance, they are the team to beat.
- Jacksonville Jaguars: After a disappointing 4-13 season, the Jaguars have added dynamic playmaker Travis Hunter in the draft, bringing hope for a turnaround.
- Indianapolis Colts: With a solid arsenal of pass catchers and a robust offensive line, the Colts are expected to exceed their 7.5 win projection.
- Tennessee Titans: Rookie QB Cam Ward brings new energy and potential, making the Titans a dark horse in the division.
Betting Insights
- Colts OVER 7.5 wins (-105): With a strong offensive lineup and a solid defense, the Colts are well-positioned to surpass expectations.
- Jaguars UNDER 7.5 wins (Even): Despite the addition of Travis Hunter, questions remain about the team's overall consistency and performance.
- Titans OVER 5.5 wins (-175): Cam Ward's arrival and a favorable schedule could help the Titans exceed their win total.
AFC South Odds
Team | Super Bowl | Conference | Division | Wins (O/U) | Playoffs (Y/N) | |
---|---|---|---|---|---|---|
Houston Texans | 25-1 | 12-1 | +100 | 9.5 (+105 O, -125 U) | (-145 | +125) |
Jacksonville Jaguars | 75-1 | 40-1 | +300 | 7.5 (-120 O, +100 U) | (+170 | -200) |
Indianapolis Colts | 100-1 | 50-1 | +350 | 7.5 (-105 O, -115 U) | (+200 | -240) |
Tennessee Titans | 250-1 | 150-1 | +750 | 5.5 (-175 O, +150 U) | (+425 | -650) |
For the most up-to-date odds, visit ESPN BET.
Did You Know?
- The Texans have never won 10 games in three consecutive seasons.
- The Colts have not won a season opener in the last 11 seasons.
- Travis Hunter is a top contender for both Defensive and Offensive Rookie of the Year.
- Cam Ward has the second-shortest odds to win Offensive Rookie of the Year.
As the 2025 NFL season approaches, the AFC South promises to be one of the most competitive divisions, with each team bringing unique strengths and potential surprises.